ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1611168
This article is part of the Research TopicWhat's on the Horizon for Asthma Treatment?View all articles
THE EFFECTS OF BENRALIZUMAB ON LUNG VOLUME CHANGES DURING EXERCISE IN EXPERIMENTAL SETTING IN SEVERE ASTHMATICS: A PILOT STUDY
Provisionally accepted
Alida Benfante
Alessandra Tomasello
Lorena Gentile
Alessia Leonarda LisottaPaola Marasà
Salvatore Battaglia
Nicola Scichilone*- University of Palermo, Palermo, Italy
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Benralizumab shows a positive effect in improving inspiratory capacity at rest and during exercise. Dynamic hyperinflation disappeared after treatment with benralizumab, improving daily activities and quality of life.We would like to submit the article for the potential publication in Frontiers in Pharmacology, to the research topic "What's on the Horizon for Asthma Treatment?". We measured the inspiratory capacity changes to evaluate the occurrence of static and dynamic hyperinflation in experimental settings resembling daily activities, confirming the occurrence of dynamic hyperinflation in severe asthmatics, and demonstrating that a 6-month period of treatment with biologic drug is able to significant increase inspiratory capacity at resting condition, and to reduce the occurrence of dynamic hyperinflation. We believe that the topic addressed is of great importance in clinical practice, in that, it addresses the hot topic of managing respiratory patients suffering from severe asthma.
Keywords: dynamic hyperinflation, Inspiratory Capacity, Severe asthma, Exercise, benralizumab
Received: 13 Apr 2025; Accepted: 04 Jul 2025.
Copyright: © 2025 Benfante, Tomasello, Gentile, Lisotta, Marasà, Battaglia and Scichilone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nicola Scichilone, University of Palermo, Palermo, Italy
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