CASE REPORT article
Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1612315
Micronized Purified Flavonoid Fraction [Daflon] induced bradycardia -a case report
Provisionally accepted
- 1University of São Paulo, Ribeirão Preto, Ribeirão Preto, Brazil
- 2State University of Goiás, Anápolis, Goiás, Brazil
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Introduction: Flavonoids are oral venoactive drugs frequently prescribed to relieve the symptoms of chronic venous disorders. Micronized purified flavonoid fraction (MPFF, commercial Daflon 1000mg) is a preparation that contains mainly diosmin and a small fraction of hesperidin. Both active ingredients are flavonoids, known by their hallmark of anti-inflammatory and antioxidant properties. Objective: Here, it was examined whether association the micronized purified flavonoid fraction (MPFF) can alter hemodynamic behavior. Methods: Daflon 1000mg was administered for 60 days and the hemodynamic parameters were measured during the circadian cycle. Results: There are no significant differences for systolic blood pressure (100.1±10.6 mmHg vs 104.8±7.7mmHg) or diastolic blood pressure (73.8±3.1mmHg vs 76.4±6.6 mmHg) before and after MPFF intake, respectively (p>0.05). However, in sharp contrast, heart rate reduced significantly after intake of MPFF (88.8±10.5 bpm vs 79.3±9.7 bpm; p<0.05). The mean blood pressure is negatively correlated with HR at afternoon period of the day (r=-0.450, p=0.016). Along this period, there was a decrease in vein inflammation and varicose, as shown by magnetic resonance imaging. Conclusion: We reported a new effect of MPFF as an attenuator of heart rate. Since venous insufficiency decreased in the observed drug administration period, further studies must examine whether the ability of diosmin and hesperidin on reducing vein disorders is directly linked to their action upon heart rate.
Keywords: Chronic venous disorders, Flavonoids, Blood Pressure, Diosmin, Hesperidin
Received: 15 Apr 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Rodrigues, Graças and Machado. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jhennyfer Aline Lima Rodrigues, University of São Paulo, Ribeirão Preto, Ribeirão Preto, Brazil
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