ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Pharmacogenetics and Pharmacogenomics
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1614753
Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period
Provisionally accepted
- 1Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- 2Shanghai Shidong Hospital of Yangpu District, Shanghai, China
- 3Department of Hepatobiliary, Pancreatic and Liver Transplantation Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
- 4Key Laboratory of Computational Biology, Chinese Academy of Sciences (CAS), Shanghai, Shanghai, China
- 5Nutrition Engineering Laboratory, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, China
- 6International Peace Maternity and Child Health Hospital, Shanghai, Shanghai Municipality, China
- 7Department of General Surgery, Xiang'an Hospital, Xiamen University, Xiamen, Fujian Province, China
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Recent guideline using tacrolimus proposed by CPIC attempts to provide information on the association of CYP3A5 genotypes with patient drug metabolic status but does not conform to the genetic characteristics of liver transplantation population. In term of this, we presented a novel tacrolimus clearance clinical-FIS (Fast-Intermediate-Slow) classification, and then proposed a novel prospective genetic-EIP (Extensive-Intermediate-Poor) classification as a genotyping basis for precisely predicting the clinical-FIS, which could possibly become a new clinical guide for tacrolimus regimen in China, and complement, refine, and elucidate clinical genotypes from the perspective of molecular and genetic biology.
Keywords: Liver Transplantation, Tacrolimus, gene polymorphism, drug metabolism, personalized medicine
Received: 19 Apr 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Fan, Wen, Yuan, Xia, Hu, Zhang and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Junwei Fan, Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Xiaoqing Zhang, International Peace Maternity and Child Health Hospital, Shanghai, 200000, Shanghai Municipality, China
Zhihai Peng, Department of General Surgery, Xiang'an Hospital, Xiamen University, Xiamen, Fujian Province, China
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