SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1615910
This article is part of the Research TopicFood Derived Bioactive Metabolites: Unlocking their Potential Health Benefits and Medical PotentialView all 13 articles
A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: A Focus on Mechanisms of Action from Preclinical Studies
Provisionally accepted
- 1The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
- 2Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
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Background: Resveratrol is a natural polyphenolic compound that shows great potential in neuroprotection, anti-inflammation，and antioxidation. Previous studies have demonstrated that resveratrol can effectively treat various animal models of retinal diseases. Purpose: The aim of the research was to use an animal experimental model to assess the effectiveness of resveratrol in treating retinal-related diseases in various animal models of retinal diseases such as ischemia-reperfusion injury, diabetic retinopathy, glaucoma, chronic ocular hypertension, optic neuritis, age-related macular degeneration, and retinopathy of prematurity. Furthermore, this study aims to reveal the underlying mechanisms of resveratrol related to the treatment of retina-related diseases. Methods: A search was conducted across several databases, including PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, and OVID. The search time was from the establishment of the database to October 2024 to collect studies on resveratrol intervention in animal models of retinal diseases. The studies included in this paper adopted the SYRCLE's risk of bias tool. Stata 16.0 and RevMan 5.4 software were used to analyze and visualize the results. Results: Resveratrol improves retinal diseases through multiple mechanisms: i) Neuroprotection: it activates the SIRT1/NF-κB and Nrf2 pathways, inhibits Caspase-3 expression, and promotes the survival of RGCs and ii) Antioxidation: it upregulates SOD activity, reduces the levels of MDA and ROS, and alleviates oxidative damage and iii) Anti-inflammation: it inhibits the COX-2, TNF-α, IL-6, and NF-κB pathways, alleviating the inflammatory response. These mechanisms resulted in enhanced amplitude of A/B waves, improved retinal thickness and visual function. Conclusion: Resveratrol has neuroprotective, anti-inflammatory and antioxidant effects through multiple mechanisms, thereby reducing retinal damage and maintaining the structure and function of the retina. This provides preclinical support for its possible therapeutic uses in the management of retinal diseases.
Keywords: resveratrol, Retinal disease, Animal Models, Systematic review, mechanisms
Received: 22 Apr 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Min Lv, LI, Chen and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiao min Min Lv, The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
Cheng Sun, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
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