Effect of exosomes derived synovial mesenchymal stem cells on cartilage repair: a systematic review

Jiemao Su¹Yansong Qi^1*Lin Niu¹Yongxiang Wang¹Wei Bao-Gang¹Bingxian Ma¹Keyu Kong²Zanjing Zhai²Yongsheng Xu^1*

• ¹Inner Mongolia People‘ Hotpiatal’, Hohhot, China
• ²Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China

Knee osteoarthritis (KOA) is the most widespread degenerative disease in the cumulative population. With the increasing aging of the population, KOA has become one of the most important factors leading to joint deformities in middle-aged and elderly people. Current studies on the treatment of KOA have focused on the early and middle stages of KOA, delaying the progression of KOA to avoid joint arthroplasty. Cartilage injury is one of the main factors leading to the progression of KOA. At present, the use of stem cell therapy for cartilage injury has become an increasingly accepted treatment plan. Stem cells contain a large number of substances to treat cartilage injury, among which exosomes are the most studied. Exosomes, as membrane-bound vesicles, treat KOA through a paracrine mechanism. And because of its own characteristics, compared with the direct use of stem cell therapy has a unique advantage.Some studies have shown that exosomes derived from synovial mesenchymal stem cells (SMSC) have significantly higher effects on knee joint than those derived from other types of MSC. However, the existing literature is still insufficient to clearly discuss the effectiveness of exosomes from synovial stem cells in treating KOA. The aim of this study is to systematically review the literature to evaluate the effectiveness of exosomes from SMSC in the treatment of knee cartilage injury.