ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1618190
The effect of remimazolam and propofol on post-hysteroscopy sleep quality under general anesthesia: a post-hoc analysis
Provisionally accepted
- Obstetrics & Gynecology Hospital, Fudan University,, Shanghai, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background:This post-hoc analysis trial compared the impacts of remimazolam and propofol anesthesia on sleep quality and fatigue after hysteroscopic surgery.:The post-hoc analysis excluded patients with a Pittsburgh Sleep Quality Index (PSQI) score > 15 or incomplete data. Preoperative PSQI scores were compared between patients receiving remimazolam and propofol. Intraoperative monitoring was conducted using the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale. Postoperative sleep and fatigue were assessed using the Athens Insomnia Scale (AIS) and Fatigue Scale-14 (FS-14) via WeChat questionnaires on the first and second postoperative days. Results: Fifteen patients were included in this post-hoc analysis. No significant differences were observed in AIS scores on postoperative days 1 and 2. Compared to the remimazolam group, patients in the propofol group experienced more awakenings (1 [0, 2] vs. 2 [1, 3], p = 0.029) and poorer sleep quality (1 [0, 2] vs. 2 [1, 2], p = 0.043) on the first postoperative day. FS-14 scores indicated higher fatigue in the propofol group on the first postoperative day (5 [3, 8] vs. 3 [2, 6], p = 0.035) with no significant difference on the second day. No intraoperative awareness was reported, and anesthesia satisfaction was similar between the two groups.The post-hoc analysis revealed that remimazolam reduced fatigue, particularly mental fatigue, on the first postoperative day compared to propofol in patients undergoing hysteroscopic surgery, despite no significant differences in AIS scores. Further research is needed to explore these effects in longer surgical procedures.
Keywords: Remimazolam, Fatigue scale, Post-hysteroscopy Sleep Quality, post-hoc analysis, Crossover trial, Hysteroscopic surgery
Received: 25 Apr 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Yang, Zhang, Cheng, hu, Nie, Sun and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shen Sun, Obstetrics & Gynecology Hospital, Fudan University,, Shanghai, China
Shaoqiang Huang, Obstetrics & Gynecology Hospital, Fudan University,, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.