ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1619481
This article is part of the Research TopicExploring Novel In Vitro Models for Cystic Fibrosis ResearchView all articles
Optimization of Ivacaftor-loaded Solid Lipid Nanoparticles for Solubility Enhancement
Provisionally accepted
- 1ICFAI University, Himachal Pradesh, Baddi, India
- 2Ganpat University, Mehsana, Gujarat, India
- 3Chitkara University, Chandigarh, Punjab, India
- 4Silpakorn University, Taling Chan District, Thailand
- 5Marwari University, Rajkot, India
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The present investigation is focused on the development and optimization of SLN (Solid Lipid Nanoparticles) formulation of IVF (Ivacaftor). IVF-SLN was formulated with the help of homogenization and ultrasonication methods by incorporating Labrasol as liquid lipid, Cetyl palmitate as solid lipid and Polysorbate 20 as the surfactant. The independent variables such as the amount of Lipid (X1) and amount of surfactant (X2) were studied for their effect on dependent variables namely entrapment efficiency and particle size. The final formulation of IVF-SLN showed a narrow range in size distribution with the particle size of 150.23 ± 1.59 nm, PDI of 0.256 ± 0.014 and entrapment efficiency of 90.54 ± 1.32%. IVF incorporation into the imperfect crystal lattice was confirmed with the help of a DSC (Differential Scanning Calorimetry) study. In-vitro and In-vivo diffusion showed enhanced profiles for the optimized formulation of IVF-SLN.
Keywords: CFTR modulator, Solid-Lipid Nanoparticles, Solubility enhancement, In-vitro diffusion, Bioavailability enhancement
Received: 28 Apr 2025; Accepted: 25 Jul 2025.
Copyright: © 2025 Parihar, Prajapati and Paliwal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bhupendra Gopalbhai Prajapati, Chitkara University, Chandigarh, 160 009, Punjab, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.