REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1620087
Grape by-products from the wine industry -an untapped sustainable resource for application in animal skin health preservation and treatment
Provisionally accepted
- 1School of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Brisbane, Australia
- 2ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (CEA-StAR), The University of Queensland, Brisbane, Australia
- 3Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
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The all-wine industry is projected to generate over US$528 billion in sales globally by 2025, and like many mass-producing industries, it too generates significant waste and by-products, much of which ends up in landfill. Among the various agricultural and industrial by-products, residues from winemaking stand out for their exceptionally rich and diverse bioactive compound content, primarily originating from grape skins, seeds and stems, all of which are rich in polyphenols, organic acids and tannins. These compounds have remarkable antioxidant, antimicrobial and anti-inflammatory properties and can therefore be diverted to agricultural, food preservation, cosmetic and pharmaceutical industries. The mechanism of action of the array of bioactive compounds includes disruption of microbial cell membranes, reduction of oxidative stress, and modulation of inflammatory responses. The current literature is limited to highlights of the scale of waste generated, and the application of its bioactive agents, however, it is notably absent of critical appraisal and discussion in sustainable avenues for development and value-added products, which are comprehensively elaborated herein.
Keywords: Wine by-products, antimicrobial, animal skin infections, Polyphenols, antimicrobial resistance, animal healthcare applications
Received: 29 Apr 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Chen, Jayasree, Pandey, Ziora and Parekh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Anjana Jayasree, School of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Brisbane, Australia
Harendra S Parekh, School of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Brisbane, Australia
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.