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REVIEW article

Front. Pharmacol.

Sec. Neuropharmacology

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1620533

Neuroprotective Mechanisms of Buyang Huanwu Decoction in Ischemic Stroke

Provisionally accepted
Yuanyuan QinYuanyuan Qin1Shiliang HuShiliang Hu2Shiman MawenShiman Mawen2Shanyao PanShanyao Pan2Yaping HuaiYaping Huai3Guoqiang LiangGuoqiang Liang1Ting ChenTing Chen1Feiyan ZhaoFeiyan Zhao1Hongli DongHongli Dong1Xuyi YaoXuyi Yao1Xue WuXue Wu1Zhigang LvZhigang Lv4Jiao DengJiao Deng4Fei HuangFei Huang1Li LuoLi Luo2*
  • 1Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China
  • 2School of Physical Education and Sports Science, Soochow University, Suzhou, China
  • 3Department of Rehabilitation Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, China
  • 4Department of rehabilitation medicine, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, China

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Ischemic stroke (IS) continues to be a major contributor to global mortality and long - term disability. Buyang Huanwu Decoction (BHD), a traditional Chinese medicine formula, has shown effectiveness in reducing brain injury and promoting post - stroke recovery through experimental researches and clinical trials. The neuroprotective mechanisms of BHD against cerebral ischemic injury involve multiple pathways, such as suppression of inflammation, reduction of oxidative stress, inhibition of apoptosis, regulation of autophagy, and enhancement of mitochondrial function. Moreover, BHD presents therapeutic potential by boosting neuroplasticity, enhancing angiogenesis, reducing excitotoxicity, optimizing brain energy metabolism, and regulating gut microbiota. Considering the current scarce effective treatments for IS, exploring BHD's therapeutic potential and its mechanism holds substantial clinical significance. This review systematically organizes recent research advancements on BHD's application in IS management and its underlying mechanisms, providing useful insights for future research and clinical practice.

Keywords: ischemic stroke, Buyang Huanwu Decoction, Neuroinflammation, Oxidative Stress, Neuroprotection

Received: 29 Apr 2025; Accepted: 30 Aug 2025.

Copyright: © 2025 Qin, Hu, Mawen, Pan, Huai, Liang, Chen, Zhao, Dong, Yao, Wu, Lv, Deng, Huang and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Li Luo, School of Physical Education and Sports Science, Soochow University, Suzhou, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material