REVIEW article
Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1622974
Efficacy of Platelet-rich plasma injection with percutaneous endoscopic lumbar discectomy for lumbar disc herniation: a systematic review and meta-analysis
Provisionally accepted
- Jingjiang People’s Hospital, Taizhou, China
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Objective: Our aim was to compare the efficacy of percutaneous endoscopic lumbar discectomy (PELD) with or without platelet-rich plasma (PRP) injections for the treatment of lumbar disc herniation (LDH).Methods: Literature was searched in six databases from inception to 2 May 2025.Meta-analysis was performed using stata17 software.Results: Eight studies were included, comprising a total of 717 patients (349 in the treatment group and 368 in the control group). At the final follow-up, the treatment group provided lower visual analogue scale, intervertebral disc protrusion, recurrence rates, Oswestry disability index and higher intervertebral disc height, Japanese Orthopaedic Association scores, spinal canal cross-sectional area and ratio value of disc grey scale, compared to the treatment group (p > 0.05).For the treatment of LDH, PELD combined with PRP injection was a secure and promising approach. PRP injection facilitated disc remodelling after PELD, improved clinical outcomes, and reduced recurrence of LDH.
Keywords: Percutaneous endoscopic lumbar discectomy, Platelet-rich plasma injection, Lumbar disc herniation, efficacy, meta-analysis PROSPERO Identifier CRD420251044871
Received: 05 May 2025; Accepted: 15 Aug 2025.
Copyright: © 2025 Zhang, Ju and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinchun Wu, Jingjiang People’s Hospital, Taizhou, China
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