ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1623916
Combined Opioid-Sodium Aescinate Therapy in Blunt Thoracic Trauma: Retrospective Evaluation
Provisionally accepted
- Department of Thoracic Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China
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Background: Effective analgesia is crucial for patients with blunt thoracic trauma, yet the optimal analgesic approach remains controversial. This study aimed to evaluate the efficacy of opioids combined with Sodium Aescinate in blunt thoracic trauma management. Methods: Fifty patients with blunt thoracic trauma were randomly assigned to receive either opioids alone (morphine hydrochloride sustained-release tablets (MHST), Group A) or opioids combined with Sodium Aescinate (Group B). Pain scores, respiratory parameters, complications, and hospitalization metrics were assessed. Results: When pain number rating scale (NRS) scores reached ≤4, Group B required significantly lower opioid doses throughout therapy. Group B demonstrated significantly higher FEV1, FVC, and arterial PO2, and lower PCO2 compared to Group A, while respiratory rates remained similar between groups. Opioid-related complications (nausea, constipation) were significantly reduced in Group B, which also experienced shorter hospital stays and lower costs. Conclusion: This study demonstrated synergism between opioids and Sodium Aescinate in providing effective analgesia. The combination therapy offers an efficient and economical approach for pain management in blunt thoracic trauma, with improved respiratory function and reduced opioid-related complications.
Keywords: blunt thoracic trauma, Opioids, Sodium aescinate, Analgesic effect, combined therapy
Received: 07 May 2025; Accepted: 27 Aug 2025.
Copyright: © 2025 Zhang, Yan and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhiyu Guan, Department of Thoracic Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China
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