REVIEW article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1624080
Orexin-A and Motion Sickness: A Systematic Review of Animal Model Studies
Provisionally accepted
- 1Naval Medical Univestiy, Shanghai, China
- 2The 988th Hospital of PLA Joint Logistics Support, Zhengzhou, China
- 3Naval Medical University, Shanghai, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
1. Initial evidence supporting orexin-A's role in reducing motion sickness symptoms and its underlying mechanisms comes from a systematic review of animal studies.2. Orexin-A effectively modulates hypothalamic nuclei (ARC, PVN), vagal outflow, and vestibular function, with distinct regulatory roles for the OX1R/OX2R receptor subtypes, thereby reducing nausea, vomiting, and motor disturbances.3. Nasal delivery and various intervention techniques highlight orexin-A's potential as a novel anti-motion sickness agent due to its quick and sensible approach.4. Data obtained from animal models emphasize the need for clinical studies and further mechanistic research to confirm orexin-A's efficacy and safety in humans.
Keywords: orexin-A, Motion Sickness, Systematic review, neural mechanisms, Therapeutic potential
Received: 07 May 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Cai, Zhao, Wang, Chen, Yuan, Gao and You. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Biao Gao, Naval Medical Univestiy, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.