REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1624569
This article is part of the Research TopicReviews in Ethnopharmacology: 2025View all 24 articles
Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review
Provisionally accepted
- 1First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
- 2Heilongjiang University of Chinese Medicine, Harbin, China
- 3Shaoxing Maternal and Child Health Hospital, Shaoxing, China
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Endometriosis (EMs) is a prevalent benign gynecological disorder characterized by dysmenorrhea and infertility, significantly impacting women's health and quality of life. Currently, the pathogenesis of EMs remains incompletely elucidated. There are various side effects of drug treatment, while surgical interventions involve a certain degree of tissue trauma. Therefore, novel therapeutic drugs and clinical strategies should be developed. Apoptosis, a programmed cell death pathway, maintains tissue homeostasis, and its dysregulation is linked to various diseases and pathological complexities.Accumulating evidence suggests that abnormal apoptosis is intricately linked to the development and progression of EMs and that targeted promotion of cell apoptosis may contribute to the prevention and treatment of EMs. Natural metabolites, with their biological properties such as multipathway and multitarget effects, exhibit unique advantages in treating EMs, possibly by regulating apoptosis. This paper reviews the relationship between apoptosis and EMs. It systematically summarizes the latest progress of natural metabolites in treating EMS by regulating apoptosis, offering an innovative strategy for treating EMs.
Keywords: Natural plant metabolites, Apoptosis, Endometriosis, Clinical Translation；, Signaling Pathways
Received: 07 May 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 YU, Zhu, Gao, Wang, Li and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yang YU, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
Shiying Li, Heilongjiang University of Chinese Medicine, Harbin, China
Ying Guo, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
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