Editorial: Microbiome: The Modulator of Human Health

Ji Youn Yoo¹Moumita Dutta^2*

• ¹Assistant Professor, Knoxville, United States
• ²Scientist, Kenmore, United States

(SCFA) in db/db mice which was considered to reverse the cognitive impairment in the animal group compared to their treatment counterpart. Wu et al., investigated the ameliorative effects of berberine on ulcerative colitis (UC) models using a multi-omics approach, as described in their sutdy titled "Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis." The authors applied multi omics approach (metagenomics, metabolomics, and transcriptomics) to comprehensively assess how berberine modulates the gut microbiome and bile acids (BA) metabolism to exert therapeutic effects on UC models. A few numbers of beneficial taxa decreased in the gut of UC models and liver produced primary BA enhanced during the experimental period. Berberine not only inhibited the colonization of the pathogenic bacteria but also promoted BA metabolism. The approach opened a new area to explore to understand the therapeutic impact of berberine treatment on UC patients.The studies featured in this Research Topic highlighted the central role of microbiome in deepening our understanding and improving the treatment of complex diseases. Collectively, these findings strengthen the view that microbial communities are not passive bystanders but active participants in influencing therapeutic outcomes, vulnerability to disease, and the recovery process. Gut Microbiome as well as the microbial metabolites could be an interesting area to modulate host health and host disease development.As guest editors, we are honored to have curated this diverse and impactful collection. We hope it will encourage further investigation into microbiome-host interactions and will inspire the development of microbiome-informed strategies for personalized health interventions.