CASE REPORT article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1627245
Syndrome of inappropriate antidiuretic hormone secretion induced by pramipexole: a case report and literature review
Provisionally accepted
- Xiangtan Central Hospital, Xiangtan, China
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Pramipexole, a novel dopamine receptor agonist, is widely used in the treatment of Parkinson's disease and related syndromes. While studies have demonstrated that pramipexole can cause various adverse reactions, primarily involving the central nervous system or gastrointestinal symptoms, there remains limited reporting on pramipexole-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH). This article analyzes and discusses a case of pramipexole-induced SIADH that occurred in our hospital. At the same time, we also summarize and discuss all current cases of pramipexole-induced SIADH. We anticipate these findings will serve as a valuable clinical reference to guide appropriate medication use.
Keywords: pramipexole, Syndrome of inappropriate antidiuretic hormone secretion, adverse drug reactions, ADH, SIADH
Received: 12 May 2025; Accepted: 29 Jul 2025.
Copyright: © 2025 Chen, Liu and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ke Qian Chen, Xiangtan Central Hospital, Xiangtan, China
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