REVIEW article
Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1627883
Advances in Hydrogel-Based Materials for Breast Cancer Bone Metastasis: From Targeted Drug Delivery to Bone Microenvironment Remodeling
Provisionally accepted
- The Second Affiliated Hospital of Jiaxing University, jiaxing, China
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Breast cancer has become the most common malignant tumor in women around the world, and bones are the most common part of all metastatic breast cancers. Breast cancer bone metastasis (BCBM) is the main cause of death in patients with advanced breast cancer. It is still mainly clinically palliative treatment, with problems such as systemic toxicity, low target specificity, and insufficient bone repair. Therefore, there is an urgent need to develop new therapeutic strategies to overcome these challenges. This review summarizes recent advances and innovative applications of smart hydrogel-based delivery systems for breast cancer bone metastasis, highlighting their significant potential in gene delivery and immune microenvironment remodeling. Current limitations and future research directions are also discussed.
Keywords: Breast cancer1, bone metastasis2, Drug delivery3, ，multifunctional platform4, Bone regeneration5
Received: 14 May 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Chen, Ma, Xu, Luo and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huanhuan Luo, The Second Affiliated Hospital of Jiaxing University, jiaxing, China
chenhong Qian, The Second Affiliated Hospital of Jiaxing University, jiaxing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.