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REVIEW article

Front. Pharmacol.

Sec. Neuropharmacology

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1630475

Harnessing Nanotechnology for Stem-Cell Therapies: Revolutionizing Neurodegenerative Disorder Treatments -a state-of-the-art update

Provisionally accepted
Neevashini ChengebroyenNeevashini Chengebroyen1*Anmol SeelanAnmol Seelan2Kamal Y ThajudeenKamal Y Thajudeen3Saad AlshehriSaad Alshehri3Aritra BiswasAritra Biswas4Israrahmed AdurIsrarahmed Adur5Vino SundararajanVino Sundararajan6*Sajitha Lulu SSajitha Lulu S6Harpreet SinghHarpreet Singh7*
  • 1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia
  • 2Department of Biological Sciences, Sunandan Divatia School of Science, Narsee Monjee Institute of Management Studies (NMIMS), Mumbai, India
  • 3Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
  • 4UNESCO Regional Centre for Biotechnology, Department of Biotechnology, Government of India, NCR Biotech Science Cluster, Faridabad, India
  • 5Manipal Institute of Regenerative Medicine (MIRM), Manipal Academy of Higher Education (MAHE), Bangalore, India
  • 6Integrative Multiomics Lab, School of Bio-Sciences & Technology, Vellore Institute of Technology, Vellore, Vellore, India
  • 7Faculty of Pharmacy, IFTM University Lodhipur Rajput Moradabad, Uttar Pradesh, Moradabad, India

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1. The review explores how nanomaterials enhance stem-cell therapy efficacy in neurodegenerative disease treatments.2. It highlights the therapeutic potentials of various stem cells, including embryonic, induced pluripotent, and adult neural stem cells.3. Focus is placed on how nanomaterials improve stem-cell generation, scaffolding, and delivery for neuronal recovery and therapy monitoring.4. The review outlines future research needed to integrate nanotechnology with stem-cell therapies for better clinical outcomes in neurodegenerative disorders.

Keywords: Nanomaterial-conjugated regenerative therapy, Neurodegenerative disorders, Nanomedicine, Scaffold, Neuroprotective-Nanotechnology Stem-cell Therapy, Nanotechnology

Received: 17 May 2025; Accepted: 26 Jun 2025.

Copyright: © 2025 Chengebroyen, Seelan, Thajudeen, Alshehri, Biswas, Adur, Sundararajan, Lulu S and Singh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Neevashini Chengebroyen, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia
Vino Sundararajan, Integrative Multiomics Lab, School of Bio-Sciences & Technology, Vellore Institute of Technology, Vellore, Vellore, India
Harpreet Singh, Faculty of Pharmacy, IFTM University Lodhipur Rajput Moradabad, Uttar Pradesh, Moradabad, India

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material