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MINI REVIEW article

Front. Pharmacol.

Sec. Ethnopharmacology

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1634207

This article is part of the Research TopicNovel Natural Therapies for Infectious Diseases Using Computational and Pharmacological ApproachesView all 6 articles

Exploring Omics Strategies for Drug Discovery from Actinomycetota isolated from the Marine ecosystem

Provisionally accepted
  • 1Universidad Autónoma de Chile Santiago, Chile, Santiago, Chile
  • 2Northern Border University, Arar, Saudi Arabia
  • 3Universidad Catolica del Maule, Talca, Chile
  • 4Vietnam Academy of Science and Technology, Hanoi, Vietnam
  • 5Sun Yat-Sen University, Guangzhou, China
  • 6Kasetsart University, Bangkok, Thailand

The final, formatted version of the article will be published soon.

Marine Actinomycetota are prolific producers of diverse bioactive secondary metabolites, making them vital for drug discovery. Traditional cultivation and bioassay-guided isolation techniques often lead to the rediscovery of the same compounds, revealing the limitations of these traditional approaches and emphasizing the need for more advanced methods. The emergence of omics technologies such as genomics, metagenomics, transcriptomics, and metabolomics has dramatically enhanced the ability to investigate microorganisms by providing detailed insights into their biosynthetic gene clusters, metabolic pathways, and regulatory mechanisms. These comprehensive tools facilitate the discovery and functional analysis of new bioactive compounds by revealing the genetic blueprints underlying their biosynthesis. Omics and function-driven techniques like heterologous expression, analytical techniques (including high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy), and culture condition optimization have enabled access to previously silent or cryptic gene clusters, expanding the chemical diversity available for exploration. This review emphasizes the integration of omics-based insights with function-driven methodologies and innovative culture techniques, forming a holistic approach to unlock the extensive biosynthetic capabilities of marine Actinomycetota. Combining these strategies holds great promise for discovering new marine-derived compounds with potential therapeutic applications.

Keywords: Marine ecosystem, marine Actinomycetota, Omics approaches, Drug Discovery, Culture-independent analysis

Received: 23 May 2025; Accepted: 04 Aug 2025.

Copyright: © 2025 Narsing Rao, Quadri, Sathish, Quach, Li and Thamchaipenet. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Arinthip Thamchaipenet, Kasetsart University, Bangkok, Thailand

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