CASE REPORT article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1636142
Spermatocytic Tumor Associated With Metastases: Report of a Rare Case and Literature Review
Provisionally accepted
- Tangdu Hospital, Fourth Military Medical University, Xi'an, China
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Spermatocytic tumor (ST) is an exceedingly rare testicular neoplasm with non-specific clinical presentations, requiring histopathological confirmation for diagnosis. Radical orchiectomy remains the cornerstone of treatment, achieving favorable outcomes in most cases. However, early metastasis observed in some patients emphasizes the necessity of comprehensive systemic staging at diagnosis and rigorous postoperative surveillance. Current evidence is largely derived from case reports, limiting robust clinical guidance. Herein we present a case of pure testicular ST with synchronous multiple pulmonary metastases managed at Tangdu Hospital. Despite undergoing radical orchiectomy followed by chemotherapy, the patient exhibited disease progression. Additionally, we performed a literature review of published ST cases to summarize its clinicopathological features, treatment paradigms, and prognostic patterns. This study highlights the challenges in managing advanced ST and underscores the need for standardized therapeutic protocols.
Keywords: spermatocytic tumor, metastasis, chemotherapy, sarcomatous differentiation, disease progression
Received: 27 May 2025; Accepted: 25 Jun 2025.
Copyright: © 2025 Chen, Mou, Zhang, Zhang, Nie, Gao, Gao and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanyao Gao, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
Jianxin Qiu, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
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