ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1636312
This article is part of the Research TopicGreen Technologies and Bioactive Profiling in Aromatic and Medicinal PlantsView all articles
Ultrasound-Assisted Extraction of Peucedanum ostruthium Leaves: A Feasible Alternative to Rhizomes for Industrial Applications
Provisionally accepted
- 1Hsing Wu University, New Taipei, Taiwan
- 2Xiamen Medical College, Xiamen, China
- 3China University of Science and Technology, Taipei, Taiwan
- 4Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
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This study investigated the feasibility of using Peucedanum ostruthium leaves, typically regarded as waste, as a substitute for the widely used rhizome. To identify the optimal parameters for ultrasoundassisted extraction of P. ostruthium leaves, we used Box-Behnken design in combination with response surface methodology. The optimal parameters were as follows: ethanol, 80%; extraction temperature, 61.0°C; ultrasonication duration, 35.5 min; liquid-to-solid ratio, 20; and ultrasonic power, 249 W. The half-maximal inhibitory concentration for the inhibition of extracellular tyrosinase activity, scavenging of free radicals, and suppression of various aging-related and inflammatory enzymes by P. ostruthium leaf extract (POLE) were 62. 30, 20.62, 8.63, 40.82-91.23, and 12.8-126.4 mg/L, respectively. The minimum bactericidal concentration and minimum fungicidal concentration of POLE for the microorganisms tested in this study were 150-350 and 400-500 mg/L, respectively. Therefore, POLE exhibited strong whitening, antiaging, anti-inflammatory, and antimicrobial properties, surpassing those of the rhizome extract. Furthermore, POLE was biologically safe at concentrations of ≤500 mg/L. The extract exhibited remarkable wound healing capacity (92.5%) at 25 mg/L. The average efficiency of transdermal absorption and penetration reached 98%. A total of 34 predominant volatile organic compounds and 19 major nonvolatile organic compounds were identified in POLE. Molecular docking analysis attributed POLE's whitening effects to both phenolic acids and flavonoids and its antiaging effects to mainly flavonoids. Furthermore, POLE's anti-inflammatory and antimicrobial effects were attributed to flavonoids and coumarins. Overall, as a viable alternative to imported P. ostruthium rhizome extract, POLE holds promise for applications in cosmeceutical, healthcare, and medical products.
Keywords: antioxidant activity, Cytotoxicity, green technology, Peucedanum ostruthium, Rhizome extracts
Received: 27 May 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Chen, Wang, Kuo, Lin, Huang, Chang and Chung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ying-Chien Chung, China University of Science and Technology, Taipei, Taiwan
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