Stevia rebaudiana Bertoni as a Sweet Herbal Medicine: Traditional Uses, Potential Applications, and Future Development

Lisha Wang¹Tianying Chang²Tonggang Zhu²Wenxin Hu²Xiaodan Wang¹Chenxuan Dong¹Yu Sun¹Tianpeng Zhang¹Yue Jiang²Chunna Zhao³Yingzi Cui^2*Xing Liao^4*Jiajuan Guo^2*

• ¹Changchun University of Chinese Medicine, Changchun, China
• ²Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China
• ³Jilin Provincial Electric Power Hospital, Changchun, China
• ⁴China Academy of Chinese Medical Sciences Institute of Basic Research in Clinical Medicine, Beijing, China

Stevia rebaudiana Bertoni (S. rebaudiana for short), native to the Amambay Mountains of South America, is a sweet tasting medicinal plant with a long history of use in traditional medical systems. With the increasing global interest in natural products, their ethnopharmacological value and therapeutic potential have received growing attention from researchers, physicians, patients, and consumers. This review aims to comprehensively assess the ethnobotanical traits, traditional uses, pharmacological activities, major constituents, mechanisms of action, and safety profiles of S. rebaudiana. A comprehensive literature search was conducted using English and Chinese databases-Web of Science, PubMed, Scopus, ScienceDirect, CNKI, Google Scholar, and Elsevier-covering publications up to March 2025, including the keywords "ethnobotany", "geographical distribution", "traditional medicine", "bioactivity", "phytochemistry", "pharmacological activities" and "toxicity". Its taxonomic identity was confirmed using the Medicinal Plant Names Services (MPNS) and Plants of the World Online (POWO). Additional ethnopharmacological monographs and reference works were consulted to supplement database coverage.These findings show that S. rebaudiana has been traditionally used to lower blood glucose levels, reduce inflammation, and promote digestion. Modern research has identified bioactive metabolites, such as diterpenes, flavonoids, and phenolic acids, which exhibit antioxidant, anti-inflammatory, neuroprotective, and hepatoprotective effects. These properties have therapeutic potential for the management of metabolic disorders, cardiovascular diseases, neurodegenerative conditions and liver dysfunction.Although generally recognized as safe, some studies have reported immunological and reproductive concerns under high-dose or prolonged exposure, underscoring the need for further toxicological and clinical evaluation.In conclusion, this review bridges traditional ethnomedical knowledge with modern pharmacological evidence, providing a foundation for future research and the potential clinical translation of S. rebaudiana in phytotherapy.