ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1639032
Mirabegron for intramural ureteral stones with vesical irritability: a prospective study
Provisionally accepted
- The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
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Objective To assess the efficacy of mirabegron in patients with intramural ureteral stones (6-10 mm).We prospectively randomized 92 patients with intramural ureteral stones into two groups. Patients in the mirabegron group received 50 mg of mirabegron daily, while those in the tamsulosin group received 0.4 mg tamsulosin daily. All patients were required to use the Urinary Sensation Scale (USS) to assess the urinary urgency and the Visual Analog Scale (VAS) to assess pain. Patients were followed until stone expulsion or for up to 4 weeks. Results all of 80 patients were included in this study. 41 patients in mirabegron group and 39 patients in tamsulosin group as control. The average expulsion time was shorter in mirabegron group than in tamsulosin group (8.4 ± 2.9 vs. 11.2 ± 3.1 days, P< 0.0001).The stone expulsion rate (SER) was higher in mirabegron group than in tamsulosin group on 1 and 2 weeks (36.6% vs. 15.4%, P=0.031 and 75.6% vs. 43.6%, P=0.004).However, the SER on 4 weeks had no statistical difference between two groups (P > 0.05). Post-treatment VAS and USS scores were lower in mirabegron group than tamsulosin group (P < 0.05).Mirabegron not only accelerates the expulsion of intramural ureteral stones but also relieves renal colic and vesical irritability.
Keywords: Adrenergic beta-3 Receptor Agonists, Mirabegron, overactive bladder, Ureteral Calculi, Urinary tract symptoms
Received: 01 Jun 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Dai, She and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hao Wang, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
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