REVIEW article
Front. Pharmacol.
Sec. Drug Metabolism and Transport
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1639646
This article is part of the Research TopicThe Exposome and Cancer: Unraveling the Complex Interplay of Environment, Lifestyle, and GeneticsView all articles
The Impact of the Exposome on Cytochrome P450-Mediated Drug Metabolism
Provisionally accepted
- American University in Cairo, Cairo, Egypt
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The cytochrome P450 (CYP450) family of enzymes plays a vital role in drug metabolism, toxicity, and individual responses to medications. Recent research has shown how the exposome, the sum of internal and external exposures during a person's lifetime, significantly affects CYP450 function. This review aims to investigate how different components of the exposome, including external factors such as dietary substances, lifestyle choices, environmental pollutants, and internal factors such as gut microbiota, hormone fluctuations, and disease states, alter CYP450 expression and function, which in turn impacts drug metabolism and treatment outcomes. This review sheds light on the potential of personalized medicine. It offers the promise of producing safer and more effective drug therapies in an increasingly dynamic exposure landscape by highlighting the molecular pathways that connect these exposures to alterations in drug-metabolizing enzymes and their function.
Keywords: Cytochrome P450 (CYP450), drug metabolism, Exposome, Environmental exposures, Internal exposures, External exposures, drug response variability
Received: 03 Jun 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Ali, Hanna, Alziny, Mahmoud, Borham, Mustafa and Abdelnaser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: A. Abdelnaser, anwar.abdelnaser@aucegypt.edu
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