REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1642248
This article is part of the Research TopicThe Vascular System: Effects of Traditional Medicines and Mechanism of ActionView all 16 articles
Regulation mechanism of curcumin mediated inflammatory pathway and its clinical application：A Review
Provisionally accepted
- 1Shenyang Anning Hospital, Shenyang, China
- 2China Medical University, Shenyang, China
- 3the Fourth People's Hospital of Shenyang Affiliated to China Medical University, Shenyang, China
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Curcumin, a natural polyphenolic compound derived from Curcuma longa, has shown great potential in the prevention and treatment of chronic inflammatory diseases due to its significant antioxidant and anti-inflammatory properties. This article aims to systematically review the anti-inflammatory molecular mechanism, clinical application prospects and challenges of curcumin. By searching the databases of Web of Science, PubMed, Google Scholar and CNKI, and integrating the latest research progress, it was found that curcumin exerted its core anti-inflammatory effects mainly by inhibiting the activation of nuclear factor-κB (NF-κB) signaling pathway, regulating the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) phosphorylation cascade, and regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway.Pharmacological studies have confirmed the therapeutic value of curcumin in a variety of inflammation-related diseases, including neurodegenerative diseases, inflammatory bowel disease, atherosclerosis, diabetes and tumors. Although curcumin has good safety and extensive sources, its inherent low bioavailability severely limits its clinical application. This review points out that combining cutting-edge technologies such as new nano-delivery systems, optimizing the delivery efficiency of curcumin and exploring its anti-inflammatory mechanism in depth are the focus of future research, which is expected to promote it to become a more effective clinical antiinflammatory drug.
Keywords: Curcumin, inflammatory pathways, Molecular mechanisms, clinical applications, Nano-delivery system
Received: 06 Jun 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Liu, Wang, Song and Pei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhen Song, Shenyang Anning Hospital, Shenyang, China
Yong Pei, the Fourth People's Hospital of Shenyang Affiliated to China Medical University, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.