SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Efficacy and safety of Chinese herbal medicine for metabolic conditions: A systematic review and meta-analysis of randomised controlled trials
Provisionally accepted
- Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background and purpose: Observational studies indicate a high prevalence of dampness syndrome in metabolic diseases from the perspective of traditional Chinese medicine theory. This systematic review and meta-analysis aimed to assess the efficacy and safety of Chinese herbal medicine (CHM) for metabolic conditions via the therapeutic approach of eliminating dampness. Materials and methods: Six medical databases were searched up to August 2024 to identify randomised controlled trials (RCTs) involving individuals with type 2 diabetes mellitus (T2DM), hypertension, dyslipidaemia, or obesity, where the intervention included oral CHM targeting dampness. Risk of bias was assessed using the Cochrane Collaboration’s tool. Meta-analyses and forest plots were generated using Review Manager 5.3. Results: Meta-analyses of 122 RCTs (n=11,252 participants)showed that dampness-eliminating CHM, when combined with lifestyle interventions, improved fasting plasma glucose (FPG), diastolic blood pressure (DBP), and body mass index (BMI), but exerted limited impacts on 2-hour postprandial glucose (2hPG) and systolic blood pressure (SBP). When used as an adjunct to pharmacotherapy, CHM significantly enhanced reductions in FPG, 2hPG, SBP, and DBP. The effects of CHM on lipid profiles were modest and uncertain. Although dampness-eliminating CHM as a whole conferred benefits for obesity, no outstanding formula with robust evidence was identified. Across all included RCTs, no additional adverse events were observed compared to pharmacotherapy alone. Promising CHM formulae included Gegen Qinlian Decoction for diabetes and Banxia Baizhu Tianma Decoction for hypertension. Poria, derived from the sclerotia of Poria cocos (Schw.) Wolf., emerged as a key component across multiple conditions. Overall, while the meta-analysis suggested promising findings for dampness-eliminating CHM in modulating metabolic conditions, the certainty of evidence was limited due to heterogeneity and lack of blinding. Specifically, the quality of evidence for individual CHM formulae was unsatisfactory, as most studies were of small scale. Conclusion: Dampness-eliminating CHM may serve as a complementary therapy for metabolic diseases such as hypertension and diabetes. Further high-quality RCTs are required to confirm its role in dyslipidaemia and identify the most effective CHM formulae for obesity.
Keywords: Chinese herbal medicine, Metabolic Diseases, Dampness, Systematic review, Meta-analysis
Received: 11 Jun 2025; Accepted: 05 Nov 2025.
Copyright: © 2025 Liang, Yu, Ren, Ren, Chen, Zhang, Cai and Ni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaojia Ni, grace1984325@126.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.