Metabolites of Astragalus membranaceus and Their Pro-Apoptotic and Cytotoxic Activities: Insights into Targeted Metabolic Pathways

Jie Liu¹Dongwei Wang²Na Ren³Li Zhang⁴Ting Wang^5*

• ¹Office of shandong College of traditional Chinese Medicine, Yantai, China
• ²Department of Proctology, Jinan Huaiyin People's Hospital, Jinan, China
• ³Pharmacy Department, Jinan Municipal People's Government Organs Outpatient Department, Jinan, China
• ⁴Pharmacy Department, Community Health Service Centre of Guyunhu Street, Jinan, China
• ⁵Department of Pharmacy, Jinan Third People's Hospital, Jinan, China

Astragalus membranaceus (Astragalus), a traditional Chinese herbal medicine, is well known for its immunomodulatory effects. Recent studies have demonstrated that Astragalus exhibits antiviral, anti-inflammatory, anti-aging, anti-atherosclerotic, antioxidant, and immune-enhancing activities, as well as pro-apoptotic and cytotoxic effects on tumor cells. It is increasingly used as an adjuvant therapy in oncology. The mechanisms underlying its pro-apoptotic and cytotoxic activities include inhibition of tumor cell proliferation and migration, modulation of tumor-associated metabolic pathways, induction of tumor cell apoptosis, cell cycle arrest, regulation of autophagy, targeting of the tumor microenvironment, inhibition of neo-angiogenesis, and enhancement of host immunity. This review provides a comprehensive summary of the active metabolites of Astragalus and their pro-apoptotic and cytotoxic mechanisms, with a focus on metabolic regulation, offering a theoretical basis for its rational application in tumor therapy. Future research aimed at precise metabolite-guided interventions could improve patient outcomes and quality of life.