MINI REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1649040
This article is part of the Research TopicReviews in Ethnopharmacology: 2025View all 34 articles
Integrated Extraction, Structural Elucidation and Hypoglycemic Mechanism of Eucommia ulmoides Polysaccharides: A Mini Review
Provisionally accepted
- 1Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
- 2Hangzhou Academy of Agricultural Sciences, Hangzhou, China
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The species Eucommia ulmoides Oliv. (EU) is gaining increasing attention from nutrition experts and health-conscious consumers due to its nutrient-providing properties. EU has been selected for inclusion in China's Medicinal Food Directory because of its high safety profile. Polysaccharides are considered the main functional component and active ingredients of this plant. Modern pharmacological studies demonstrate that these polysaccharides, as primary bio-active components of EU, exhibit multiple bio-activities including effectiveness in relieving insulin resistance in diabetes models, lowering blood sugar, and improving diabetes complication. Diabetes represents an increasingly severe global metabolic epidemic that affects millions of people's quality of life. Additionally, variations in extraction, isolation, and purification methods significantly impact the content, purity, and structural characterization of EU polysaccharides (EUP), thereby influencing its biological activity. Therefore, the present study reviewed the latest progress in the extraction, isolation, and purification methods, structural characteristics, and potential mechanisms of EUP based on a comprehensive literature search and compilation, aiming to provide a theoretical basis for in-depth research and product development.
Keywords: Eucommia ulmoides polysaccharides, extraction, purification, Structural characteristics, Hypoglycemic activity
Received: 18 Jun 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Huang, Liu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongmei Chen, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
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