MINI REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1651023
Stephania tetrandra S. Moore: A promising candidate drug for treating diabetic kidney disease
Provisionally accepted
- 1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
- 2Hubei University of Chinese Medicine, Wuhan, China
- 3Zhujiang Hospital of Southern Medical University, Guangzhou, China
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With the continuous rise in the prevalence of diabetes, it has become the primary cause of end-stage renal disease. Currently, there are no effective clinical treatments available to reverse the progression of DKD. Stephania tetrandra S. Moore, a traditional Chinese medicine, has demonstrated significant value in the prevention and treatment of DKD due to its active components. This study focuses on exploring the molecular mechanisms through which the primary active components of Stephania tetrandra, tetrandrine/sinomenine and fangchinoline, exert renal protective effects via multiple pathways, including regulating inflammatory responses, antagonizing oxidative stress, improving glomerular endothelial function, modulating podocyte damage, and intervening in lipid metabolism disorders. These findings provide a theoretical basis for the development of novel therapeutic agents for DKD.
Keywords: Diabetic kidney disease, Stephania tetrandra S. Moore, active compounds, Chinese herbal medicine, Mechanism
Received: 20 Jun 2025; Accepted: 08 Aug 2025.
Copyright: © 2025 Wang, Li, Yan, Zeng, Yan, Wang, Liang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinhui Wang, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Ying Liang, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Ren-Huan Yu, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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