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REVIEW article

Front. Pharmacol.

Sec. Pharmacogenetics and Pharmacogenomics

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1651909

This article is part of the Research TopicPharmacogenomics of Drug Hypersensitivity ReactionsView all 4 articles

Pharmacogenomics of antibiotics-induced hypersensitivity reactions: Current evidence and implications in clinical practice

Provisionally accepted
  • 1Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
  • 2Mahidol University, Salaya, Thailand

The final, formatted version of the article will be published soon.

Adverse drug reactions (ADRs) are gradually becoming a concerning health threat worldwide in patients undergoing acute or chronic therapy.. Antibiotics are the main drugs that cause immunemediated ADRs, such as SCARs, allergic reactions, and organ-specific diseases, representing an indisputable threat to patient safety. In this review, we presented the current genetic evidence available for antibiotic-related toxicities considering the pharmacogenomics (PGx) point of view.We also explored the current state of PGx-based dosing recommendations and the factors limiting their widespread application into routine clinical practice. Through the systematic literature review, this study identified at least 12 antibiotic-gene pairs (Amikacin-MT-RNR1; Gentamicin-

Keywords: antibiotics, Hypersensitivity, severe cutaneous adverse drug reactions, liver injury, pharmacogenomics, precision medicine

Received: 22 Jun 2025; Accepted: 08 Sep 2025.

Copyright: © 2025 Biswas, Murad, Ashik, Ershadian and SUKASEM. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: CHONLAPHAT SUKASEM, Mahidol University, Salaya, Thailand

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