REVIEW article
Front. Pharmacol.
Sec. Pharmacogenetics and Pharmacogenomics
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1651909
This article is part of the Research TopicPharmacogenomics of Drug Hypersensitivity ReactionsView all 4 articles
Pharmacogenomics of antibiotics-induced hypersensitivity reactions: Current evidence and implications in clinical practice
Provisionally accepted
Dr. Mohitosh Biswas1
Murshadul Alam Murad1
Md. Ismail Hossain Ashik1
Maliheh Ershadian2
CHONLAPHAT SUKASEM2*- 1Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
- 2Mahidol University, Salaya, Thailand
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Adverse drug reactions (ADRs) are gradually becoming a concerning health threat worldwide in patients undergoing acute or chronic therapy.. Antibiotics are the main drugs that cause immunemediated ADRs, such as SCARs, allergic reactions, and organ-specific diseases, representing an indisputable threat to patient safety. In this review, we presented the current genetic evidence available for antibiotic-related toxicities considering the pharmacogenomics (PGx) point of view.We also explored the current state of PGx-based dosing recommendations and the factors limiting their widespread application into routine clinical practice. Through the systematic literature review, this study identified at least 12 antibiotic-gene pairs (Amikacin-MT-RNR1; Gentamicin-
Keywords: antibiotics, Hypersensitivity, severe cutaneous adverse drug reactions, liver injury, pharmacogenomics, precision medicine
Received: 22 Jun 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Biswas, Murad, Ashik, Ershadian and SUKASEM. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: CHONLAPHAT SUKASEM, chonlaphat.suk@mahidol.ac.th
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.