MINI REVIEW article
Front. Pharmacol.
Sec. Inflammation Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1652159
This article is part of the Research TopicVolume II: Anti-Inflammatory Drug Development Focusing on Immune Mediated DiseasesView all 6 articles
Promising therapeutics of enterovirus 71 infection: sunshine behind cloud
Provisionally accepted
- 1Department of Microbiology and Immunology, National Cheng Kung University, Tainan, Taiwan
- 2Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, Taiwan
- 3Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan City, Taiwan
- 4Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan
- 5Center for Infection Control, National Cheng Kung University College of Medicine, Tainan City, Taiwan
- 6National Cheng Kung University School of Medicine, Tainan City, Taiwan
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Enterovirus 71 (EV71) infection gave a hard hit on young children because of fatal complication, brainstem encephalitis with pulmonary edema. The occurrence of severe EV71 infections highlight the urgent need for the development and repurposing of novel antivirals for medical use. Drugs target specific steps in the cycle of viral replication, and the modification of existing factors in EV71 immunopathogenesis deciphers the current approaches for developing antivirals. In addition to identifying chemical compounds, we highlight active constituents and explore underlying mechanisms of action of antimicrobial peptides and natural products that may be active against EV71 and provide pharmacological benefits.
Keywords: enterovirus 71, Brainstem encephalitis, Pulmonary Edema, antiviral, entrovirus
Received: 23 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 You, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shih-Min Wang, Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan
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