REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1652860
Therapeutic potential of plant-derived natural products against drug-induced liver injury
Provisionally accepted
- 1School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
- 2Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Drug-induced liver injury (DILI) is a major cause of drug development failure and postmarketing restrictions. To date, over 1000 drugs have been reported to cause liver damage such as acetaminophen, isoniazide, methotrexate, triptolide and so on.However, there are currently no effective therapies for DILI. Plant-derived natural products including flavonoids, phenylpropanoids, terpenoids, and glycosides have been used for the treatment of DILI due to their low toxicity and strong bioactivity.These anti-DLI compounds involve multiple mechanisms, such as reducing oxidative stress and inflammation, restoring mitochondrial function, and suppressing apoptotic. This review primarily summarizes recent advances over the past five years in the therapeutic potential of natural products against a range of commonly used hepatotoxic drugs, rather than focusing on a specific hepatotoxic agent. The insights will provide a cue for further research and promote the development of novel and effective drugs in treating DILI.
Keywords: Flavonoids, phenylpropanoids, terpenoids, Glycosides, Drug-Induced Liver Injury, Mechanism
Received: 24 Jun 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Chen, Mei, Hou and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yan Chen, School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
Lin Hou, School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
Ke-Jian Li, School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.