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CORRECTION article

Front. Pharmacol., 14 October 2025

Sec. Ethnopharmacology

Volume 16 - 2025 | https://doi.org/10.3389/fphar.2025.1653830

Correction: Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

This article is a correction to:

  1. Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

    1. Read original article
Dan Su&#x;Dan Su1†Qianmin Li&#x;Qianmin Li1†Xin LaiXin Lai1Yonggui SongYonggui Song1Huizhen LiHuizhen Li1Zhifu AiZhifu Ai1Qi ZhangQi Zhang1Wenxiang ShaoWenxiang Shao1Ming Yang,Ming Yang1,2Genhua Zhu Genhua Zhu1*
  • 1Key Laboratory of Evaluation of Traditional Chinese Medicine Efficcacy (Prevention and Treatment of Brain Disease with Mental Disorders), Key Laboratory of Depression Animal Model Based on TCM Syndrome, Jiangxi Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, China
  • 2Jiangxi Guxiang Jinyun Comprehensive Health Industry Co. Ltd., Nanchang, China

A Correction on
Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

by Su D, Li Q, Lai X, Song Y, Li H, Ai Z, Zhang Q, Shao W, Yang M and Zhu G (2024). Front. Pharmacol. 15:1424834. doi: 10.3389/fphar.2024.1424834

There was a mistake in Figure 2 as published. The cell morphology images of the “Control group”, “Model group”, and “PAR group” in Figure 2C were accidentally misused due to confusion in the naming of the experimental archive files, using some images from previous studies of the research group under the same experimental conditions. The immunofluorescence images of the “IL-1β Control group” and “IL-6 Control group” in Figure 2N were mistakenly pasted with the same control group image due to file classification errors during image export. The corrected Figure 2 appears below.

Figure 2
The image is a multi-panel scientific figure showing various charts and microscopic images. Panels A, B, D, E, F, G, H, I, and J contain bar graphs displaying cell viability and cytokine levels under different treatments. Panel C includes microscopic images of cell cultures under control and treated conditions. Panels K, L, M, and N feature fluorescence microscopy images showing staining for TNF-alpha, IL-6, and IL-1β, with associated graphs indicating fluorescence intensity. Each panel is labeled with control and treatment groups, highlighting experimental results.

Figure 2. Protective effect of HHZ on LPS-induced inflammation in BV2 cells. (A,B) CCK-8 cell viability detection of HHZ extract and its active ingredient. (C) The effect of HHZ extract and LPS on the morphology of BV2 microglial cells (100X). (D–G) ELISA detection of TNF-α and IL-6 levels in BV2 cells. (H–J) After treatment with medicated serum, the expression levels of iNOS, NO, and IL-4 in BV2 cells. (K–N) Immunofluorescence analysis of TNF-α, IL-6, IL-1β. Values represent the mean ± SD. #p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001 means significant difference compared with the control group; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 means significant difference compared with LPS group.

The original article has been updated.

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Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: sargassum pallidum, network pharmacology, inflammation, antidepressant, gut microbiota

Citation: Su D, Li Q, Lai X, Song Y, Li H, Ai Z, Zhang Q, Shao W, Yang M and Zhu G (2025) Correction: Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway. Front. Pharmacol. 16:1653830. doi: 10.3389/fphar.2025.1653830

Received: 25 June 2025; Accepted: 07 October 2025;
Published: 14 October 2025.

Edited and reviewed by:

Karim Hosni, Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Tunisia

Copyright © 2025 Su, Li, Lai, Song, Li, Ai, Zhang, Shao, Yang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Genhua Zhu, emh1Z2VuaHVhanh6eXlAMTYzLmNvbQ==

†These authors have contributed equally to this work

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.