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SYSTEMATIC REVIEW article

Front. Pharmacol.

Sec. Neuropharmacology

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1656400

Systematic Review and Network Meta-Analysis of the effects of Bioactive Compounds on pain intensity and quality of life in neuropathic pain patients

Provisionally accepted
Rong  TangRong TangChao-Yang  GongChao-Yang GongYu-Qian  LiuYu-Qian LiuYingbin  WangYingbin Wang*Hai-Yu  ZhouHai-Yu Zhou*
  • Lanzhou University Second Hospital, Lanzhou, China

The final, formatted version of the article will be published soon.

Background: In recent years, a significant number of researchers have concentrated on bioactive compounds for the treatment of neuropathic pain. However, there remains a lack of compelling evidence to robustly support their therapeutic efficacy. Objective: This study aims to assess the impact of various bioactive compounds on pain intensity and quality of life in patients suffering from neuropathic pain by conducting a network meta-analysis. Methods: Researchers conducted a systematic search across five electronic databases—PubMed, EMBASE, Cochrane Library, the Cochrane Central Register of Controlled Trials, and Web of Science—from the inception of each database until April 2025. The methodological quality of the included studies was assessed using the Cochrane Risk of Bias assessment tool. Data analysis was subsequently performed using Stata MP 15.1 software. The primary outcome measures consisted of the following standardized assessment scales: Visual Analogue Scale (VAS), Neuropathic Pain Scale (NPS), Hospital Anxiety and Depression Scale (HADS), Patient Global Impression of Change (PGIC), and Leeds Sleep Evaluation Questionnaire (LSEQ). Treatment effects were ranked based on probability values derived from the Surface Under the Cumulative Ranking Curve (SUCRA). Results: Following the screening process, 20 eligible randomized controlled trials were included, involving a total of 2,471 patients and evaluating six distinct bioactive compound-based therapeutic interventions. The ranking of treatments, based on SUCRA values, indicated that tetrahydrocannabinol was associated with the highest likelihood of being the most effective option for reducing VAS scores (SUCRA: 88.2%). Furthermore, it consistently ranked favorably across other outcomes, including NPS (84.8%), PGIC (85.1%), and LSEQ (90.7%). Capsaicin was ranked as the most promising intervention for improving HADS scores (90.1%). Conclusion: This study offers valuable insights into the application of bioactive compounds for the management of neuropathic pain. However, the research also presents certain unavoidable limitations, such as heterogeneity among studies and the absence of direct comparative evidence for specific intervention measures. Future studies should include larger sample sizes, extended follow-up periods, and more rigorously designed randomized controlled trials to definitively establish the efficacy of bioactive compounds in patients with neuropathic pain patients.

Keywords: bioactive compounds, pain intensity, Quality of Life, Neuropathic pain patients, system review and meta-analysis

Received: 30 Jun 2025; Accepted: 06 Oct 2025.

Copyright: © 2025 Tang, Gong, Liu, Wang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Yingbin Wang, 1402141673@qq.com
Hai-Yu Zhou, 3844142260@qq.com

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