CASE REPORT article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1656670
This article is part of the Research TopicAdvances in Immunosuppressive Microenvironment Remodeling and Targeted Drug Intervention in Pancreatic CancerView all 5 articles
Continuous response to Maintenance Fuzuloparib for Germline BRCA2-Mutated Metastatic Pancreatic Adenocarcinoma: a case report and literature review
Provisionally accepted
- Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China
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Pancreatic adenocarcinoma with germline BRCA mutations (gBRCAm) represents a distinct molecular subtype with enhanced sensitivity to platinum-based chemotherapy and poly (ADP-ribose) polymerase inhibitors (PARP inhibitors). Fuzuloparib is a novel, potent, and orally bioavailable PARP inhibitor. Despite showing improved efficacy and a more favorable safety profile compared to olaparib in preclinical studies, clinical evidence for its application in pancreatic adenocarcinoma harboring gBRCAm remains limited. We report here a 33-year-old Asian woman with extensively metastatic pancreatic adenocarcinoma harboring a germline BRCA2 nonsense mutation who a durable response to fuzuloparib after NALIRIFOX chemotherapy. Her progression-free survival exceeded 15 months with ongoing fuzuloparib maintenance therapy for over 7 months. This case underscores the important role of biomarker-directed therapy in pancreatic adenocarcinoma and fuzuloparib may represent a potential PARP inhibitor option for maintenance treatment in pancreatic adenocarcinoma with gBRCAm. However, large-scale randomized controlled trials are needed to validate these results..
Keywords: gBRCA-mutation, Pancreatic Cancer, PARP inhibitor, Platinum-based chemotherapy, Metastase
Received: 30 Jun 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Zhang, Zhang, Cao and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dan Cao, Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China
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