ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
The role of total polysaccharides from Sonchus arvensis L. for the prevention and treatment of colitis via regulating gut microbiota and metabolites
Provisionally accepted
- 1College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China
- 2Harbin Medical University, Harbin, China
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Background: Sonchus arvensis L. is a traditional Chinese food and medicine, and the primary plant metabolites are polysaccharides (SAP). In this study, we aimed to investigate the protective effect of SAP in a colitis model and the potential underlying molecular mechanisms. Methods: C57BL/6 mice were randomly assigned to 3 groups: negative control, model, and SAP treatment. The influence of SAP on ulcerative colitis (UC) was evaluated by water and food intake, body weight change, diarrhea, bloody stool, colon length, histological analysis, disease activity index, and immune parameters. The effects of SAP on gut microbiota (GM) were investigated using 16S rRNA sequencing. The impact of SAP on metabolites was evaluated using non-targeted metabolomic analysis. Results: SAP attenuated colitis and modified immune parameters. 16S rRNA sequencing showed that the abundance of Akkermansia, Rikenella, Rikenellaceae_RC9_gut_group, and unidentified_Clostridia_vadinBB60_group in model mice was remarkably reversed after SAP treatment. The correlation analysis of GM and metabolites showed that SAP could regulate five metabolites correlated with GM. Conclusion: The Protective effect of SAP on model mice may be related to GM diversity and metabolites.
Keywords: Sonchus arvensis L., polysaccharide, Colitis, Gut Microbiota, non-targeted metabonomic analysis
Received: 02 Jul 2025; Accepted: 25 Nov 2025.
Copyright: © 2025 Ren, hou, chen and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yulong Zhou
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