REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Integrating clinical evidence with natural product therapies for elderly-onset type 2 diabetes
Provisionally accepted
- 1Eulji University, Daejeon, Republic of Korea
- 2Mokpo National University, Muan-gun, Republic of Korea
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Elderly-onset type 2 diabetes presents a distinct clinical profile, typically characterized by milder hyperglycemia and specific risks for complications. Age-related physiological changes and increased sensitivity to side effects often limit the use of conventional medications in this population. This review summarizes the epidemiology, clinical characteristics, and management challenges of diabetes in older adults and explores the therapeutic potential of natural bioactive compounds—including Enteromorpha prolifera, Ficus species, genipin, gingerol, mulberry, myricitrin, quercetin, resveratrol, and saffron. These findings not only provide mechanistic insights into the role of natural bioactive compounds in diabetes management but also highlight their clinical relevance, suggesting potential applications as adjunctive therapies for elderly individuals with limited pharmacological tolerance, and guiding future research toward evidence-based integration of such agents into clinical practice.
Keywords: natural compounds, Aging, type 2 diabetes, diabetic complications, Hyperglycemia
Received: 03 Jul 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Oh, Kim, Kim and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yoon Sin Oh, ysoh6262@gmail.com
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