ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Renal Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1660599
Quercetin Ameliorates Renal Injury in Hyperuricemic Rats via Modulating ER Stress Pathways
Provisionally accepted
- 1Shanghai Pudong New Area People's Hospital, Pudong, China
- 2Xujiahui Street Community Health Service Center, Shanghai, China
- 3Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China
- 4Shanghai Pudong Hospital, Shanghai, China
- 5Shanghai University of Traditional Chinese Medicine, Shanghai, China
- 6Tongren Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China
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Hyperuricemia is a key risk factor for chronic kidney disease (CKD), yet effective treatments remain limited. This study demonstrates that quercetin exerts potent renoprotective effects in hyperuricemia-induced CKD through multifaceted mechanisms. In rats with hyperuricemia induced by adenine (0.1 g/kg) and potassium oxonate (1.5 g/kg), quercetin treatment (50 or 100 mg/kg) significantly improved renal function by reducing urinary ACR, serum creatinine, uric acid, BUN, and blood pressure, while alleviating renal inflammation, fibrosis, and crystal deposition. Mechanistic studies revealed quercetin's ability to suppress ER stress markers (GRP78, CHOP, p-PERK, IRE1α, ATF6), inhibit renal GLUT9 expression, and downregulate downstream inflammatory (TLR4/NF-κB/IL-1β/TNF-α), fibrotic (collagen I/α-SMA/fibronectin), and oxidative pathways, while enhancing antioxidant defenses and inhibiting apoptosis. Notably, quercetin showed superior efficacy to febuxostat (5 mg/kg), the clinical gold standard. These findings establish quercetin as a promising therapeutic candidate for hyperuricemia-associated kidney injury through its comprehensive modulation of ER stressmediated pathological processes.
Keywords: Quercetin, Hyperuricemia, kidney injury, Inflammation, Fibrosis, Oxidative Stress, er stress
Received: 06 Jul 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Liu, Yang, Wang, Wang, Pan, Wang, Chi and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhouhui Jin, Shanghai Pudong New Area People's Hospital, Pudong, China
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