REVIEW article
Front. Pharmacol.
Sec. Neuropharmacology
This article is part of the Research TopicAdvancements in Translational Stroke Research: Spotlight on the Blood-Brain BarrierView all 4 articles
Application of neural stem cells in the treatment of intracerebral hemorrhage: a systematic review
Provisionally accepted
- Renmin Hospital of Wuhan University, Wuhan, China
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[Abstract] Stroke ranks among the top global causes of death and disability, with hemorrhagic stroke accounting for 9%–27% of cases. In China, intracerebral hemorrhage (ICH) outpaces Western rates, driving adult mortality and disability. Aging populations and urbanization diversify stroke risk factors, yielding a 28-day ICH mortality rate up to 47% [2]—sharply higher than ischemic stroke's 3%—with ~75% of survivors facing permanent neurological deficits. ICH imposes heavy burdens on individuals, families, and society. Current medical and surgical treatments struggle to enhance long-term outcomes, prompting exploration of neural stem cell (NSC) transplantation. This approach replaces lost neurons via differentiation while offering anti-inflammatory, anti-apoptotic, and neuroprotective benefits. This systematic review evaluates NSC sources, delivery routes, ICH models, therapeutic mechanisms, and early clinical trials, outlining recent progress and future directions for treating hemorrhagic stroke with NSC transplantation.
Keywords: intracerebral hemorrhage, Neural Stem Cells, Transplantation, Neural Repair, Treatment
Received: 06 Jul 2025; Accepted: 20 Nov 2025.
Copyright: © 2025 Ping, Shafiq, Jiang and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiang Cai, cqno@sina.com
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