ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1661625
Xinli Formula's Efficacy in Heart Failure: Analysis via Guangdong TCM Hospital Database
Provisionally accepted
Haiming Cao1Jiongming Zhang2Tong Zhang1
Xiankun Chen3Tong Liu3
Wenjing Xu1Yi Zhu3
Wei Jiang3
Weihui Lu1*- 1Guangzhou University of Chinese Medicine, Guangzhou, China
- 2Huzhou Traditional Chinese Medicine Hospital, Huzhou, China
- 3The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Objective: To evaluate the efficacy of the "Xinli Formula" in improving cardiac function, symptoms, and quality of life in patients with heart failure using a hospital database. Methods: A retrospective study included 210 patients (2017–2022) divided into Xinli Formula group (n=107) and non-Xinli Formula group (n=103). Outcomes included cardiac function parameters, N-terminal pro-B-type natriuretic peptide(NT-proBNP) levels, 6-minute walk distance(6MWD), quality of life (Minnesota Living with Heart Failure Questionnaire, MLHFQ), and inflammatory markers. Data were analyzed using SPSS 26.0. Results: The Xinli Formula group showed significant improvements in Left Ventricular Ejection Fractions(LVEF) (38% →42%),Left Ventricular End-Systolic Diameter(LVESD) (45 mm →40 mm), Left Ventricular End-Diastolic Diameter(LVEDD) (60 mm →55 mm), and 6MWD(350 m →400 m). MLHFQ scores decreased from 45 to 30. Inflammatory markers and NT-proBNP levels also improved significantly. Conclusions: The Xinli Formula significantly improves cardiac function, exercise tolerance, and quality of life in patients with heart failure and may be an effective adjunctive therapy. Further studies are needed.
Keywords: Heart Failure, Traditional Chinese Medicine, Xinli Formula, efficacy, Hospital database
Received: 05 Aug 2025; Accepted: 22 Oct 2025.
Copyright: © 2025 Cao, Zhang, Zhang, Chen, Liu, Xu, Zhu, Jiang and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weihui Lu, weihuilu0407@163.com
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