MINI REVIEW article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1664200
The Role of Cuproptosis in the Occurrence and Development of Gastric Cancer
Provisionally accepted
- 1Zhenjiang Fourth Peoples Hospital and Zhenjiang Women and Children's Hospital, Zhenjiang, China
- 2Jiangsu University, Zhenjiang, China
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Abstract Gastric cancer has emerged as a major global public health threat due to its high incidence and mortality rates. Despite advances in diagnostic and therapeutic approaches, treatment outcomes remain unsatisfactory with frequent disease recurrence and poor prognosis. This underscores the urgent need to develop novel therapeutic strategies against gastric cancer. Cuproptosis, a novel form of cellular death, has garnered increasing attention from researchers regarding its relationship with the onset and progression of gastric cancer. This article aims to explore the molecular mechanisms of cuproptosis, its functions in gastric cancer, and its potential therapeutic applications. We analyze the driving factors and defense mechanisms of cuproptosis, as well as how it influences the growth, metastasis, and drug resistance of gastric cancer cells. Furthermore, we discuss the interplay between cuproptosis and the gastric cancer microenvironment, and consider the possibilities of this mechanism in future clinical treatments.
Keywords: cuproptosis, gastric cancer, Cellular death, Molecular mechanisms, therapeutic strategies
Received: 11 Jul 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Lu, Yang, Gu, Jin and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhaofeng Liang, liangzhaofeng@ujs.edu.cn
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