REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1667517
Advancements in Nasal Drug Delivery System of Natural Products
Provisionally accepted
Yenna Hsu1,2Jiajing Yang1,2Miaoyang Cao1,2Ting Xu1,2Jia He1,2Huarong Hong1,2Luyun Jiang1,2*Shunlin Peng1,2*
Peizheng Xiong1,2*- 1Chengdu University of Traditional Chinese Medicine, Chengdu, China
- 2Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
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Background: Nasal drug delivery offers a non-invasive route with rapid absorption and the ability to bypass first-pass metabolism, making it promising for central nervous system (CNS) disorders, nasal diseases such as allergic rhinitis, and other chronic conditions by enabling targeted delivery and crossing the blood-brain barrier. Purpose: To review the advantages of nasal delivery, therapeutic potential of natural products, and how drug delivery systems may overcome bioavailability and solubility issues. Study Design: A literature review analyzing mechanisms, clinical applications, and limitations of natural products in nasal delivery. Methods: Relevant articles published before January 2025 were retrieved from Google Scholar, PubMed, ScienceDirect, Scopus, Web of Science, Springer, and official sources. Results: Nasal administration improves the bioavailability and absorption of natural products, enhancing anti-inflammatory, antioxidant, neuroprotective, and anti-allergic effects. However, poor solubility and stability remain barriers, which may be mitigated by nanocarriers, liposomes, and other advanced systems. Conclusion: Combining nasal drug delivery with natural products is a promising strategy for treating CNS, nasal, and chronic diseases, potentially improving clinical efficacy and expanding therapeutic options.
Keywords: Nasal administration, Natural Products, allergic rhinitis, Alzheimer's disease, Nasaldrug delivery system
Received: 16 Jul 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Hsu, Yang, Cao, Xu, He, Hong, Jiang, Peng and Xiong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Luyun Jiang, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Shunlin Peng, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Peizheng Xiong, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.