ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
This article is part of the Research TopicBeyond Standardization in Knee Surgery: Time to Think PersonalizedView all 9 articles
Efficacy and Safety of Tranexamic Acid Combined with Low Molecular Weight Heparin versus Fondaparinux Sodium Following Total Knee Arthroplasty: A Retrospective Cohort Study
Provisionally accepted
- 1Sixth People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China
- 2Huashan Hospital Fudan University, Shanghai, China
- 3Shandong University, Jinan, China
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Background: Low molecular weight heparin (LMWH) and fondaparinux (FPX) are commonly used to prevent deep vein thrombosis (DVT) following total knee arthroplasty (TKA). This study aimed to compare the efficacy and safety of tranexamic acid (TXA) combined with LMWH versus TXA combined with FPX in preventing DVT among TKA patients. Methods: A retrospective cohort study was conducted involving patients who underwent unilateral TKA at our institution between January 2020 and December 2023. Patients were divided into two groups based on their anticoagulation regimen: the TXA+LMWH group (n=150) and the TXA+FPX group (n=130). Perioperative indicators (blood loss, hospital stay, operative time, transfusion rate, transfusion volume, and total hospitalization costs), complications (DVT, muscular calf vein thrombosis [MCVT], surgical site infection, pulmonary thromboembolism, and postoperative hematoma), adverse reactions, coagulation parameters (D-dimer, prothrombin activity, INR, fibrinogen), and routine blood parameters (platelet count, hemoglobin, hematocrit) were compared between groups. Results: No significant differences were observed between groups regarding preoperative baseline characteristics, perioperative blood loss, operative time, hospital stay, transfusion rate, or transfusion volume (P>0.05). On postoperative days 1 and 5, levels of D-dimer, prothrombin activity, INR, and fibrinogen were significantly lower in the TXA+LMWH group compared to the TXA+FPX group (P<0.05). Total hospitalization costs were significantly lower in the TXA+LMWH group (P<0.05). Additionally, the TXA+LMWH group exhibited a significantly lower overall complication rate (28.00% vs. 47.69%, P<0.05) and lower incidence of MCVT (20.67% vs. 32.31%, P<0.05). No significant differences were found in rates of DVT, surgical site infection, or postoperative hematoma (P>0.05). No severe complications, such as pulmonary thromboembolism, acute renal failure, seizures, or death, occurred in either group. Conclusion: TXA combined with LMWH demonstrates significant advantages over TXA combined with FPX in reducing overall complications, particularly MCVT, and lowering hospitalization costs, with favorable improvements in coagulation parameters. Both regimens showed comparable efficacy in managing perioperative blood loss, operative time, hospital stay, and transfusion requirements in TKA patients. Given the retrospective design and limited sample size, further validation through high-quality, large-scale prospective studies is warranted.
Keywords: Osteoarthritis, Total knee arthroplasty, low molecular weight heparin, fondaparinux, Coagulation parameters, Thrombosis
Received: 19 Aug 2025; Accepted: 06 Nov 2025.
Copyright: © 2025 Ainiwaer, Pan and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pengcheng Ma, anf75292@163.com
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