REVIEW article
Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1668718
SIRT1: The First key to unlocking the mystery of cardiovascular diseases
Provisionally accepted
Dinislam Khuzin1
Muneer Ahmed Khoso2
Valeriy Kataev3Svetlana Meshcheryakova3Heng Liu4Ling Liu2Madi Guo2Song Wang2Han Lou2Yong Zhang2*Xin Liu2*- 1Harbin University, Harbin, China
- 2Harbin Medical University, Harbin, China
- 3Baskirskij gosudarstvennyj medicinskij universitet, Ufa, Russia
- 4Other
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Cardiovascular disease (CVD) is the leading cause of death worldwide, encompasses various heart and vascular disorders that significantly elevate morbidity and mortality rates. Sirtuin 1 (SIRT1), a NAD+ dependent deacetylase, plays a key role in cardiovascular health and pathology by regulating fundamental processes this includes, endothelial function, oxidative stress, inflammation, senescence, metabolism, cardiac hypertrophy and heart failure. Through these mechanisms, SIRT1 emerges as critical factor in the pathophysiology of CVDs, including heart failure, atherosclerosis, hypertension, and myocardial infarction. SIRT1 modulates several cellular pathways, to regulate complex cellular processes associated with cardiovascular disorders. This review, summarizes the recent findings regarding the physiological and pathological roles of SIRT1 related to heart diseases and explores the therapeutic potential of targeting SIRT1 and sirtuin family members for CVD treatment.
Keywords: SIRT1, Cardiovascular Diseases, endothelial dysfunction, Oxidative Stress, therapeutic targets
Received: 18 Jul 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Khuzin, Khoso, Kataev, Meshcheryakova, Liu, Liu, Guo, Wang, Lou, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Zhang, zy@emss.hrnmu.edu.cn
Xin Liu, 1034781@hrbmu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.