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ORIGINAL RESEARCH article

Front. Pharmacol.

Sec. Experimental Pharmacology and Drug Discovery

Pentoxifylline Vaginal Gel Improves Sperm Mo8lity and Vitality in Asthenozoospermic Males: A Randomized, Blinded, In Vitro Study

Provisionally accepted
Cristina  TrillaCristina Trilla1,2,3,4,5*Lidia  NavarroLidia Navarro1Mariona  RiusMariona Rius1Juan José  EspinósJuan José Espinós1,3,4
  • 1Clinica Fertty, Barcelona, Spain
  • 2Prokrea BCN S.L., Barcelona, Spain
  • 3Department of Obstetrics and Gynecology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
  • 4Universitat Autonoma de Barcelona, Barcelona, Spain
  • 5Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0001), Instituto de Salud Carlos III,, Madrid, Spain

The final, formatted version of the article will be published soon.

Introduc

Keywords: Asthenozoospermia, Pentoxifylline, Sperm Motility, Sperm vitality, in vitro study, male infertility, Vaginal gel

Received: 18 Jul 2025; Accepted: 03 Nov 2025.

Copyright: © 2025 Trilla, Navarro, Rius and Espinós. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Cristina Trilla, trilla.cristina@gmail.com

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