ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Inflammation Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1673190
A double layer oral film loaded with doxepin hydrochloride for the treatment of chemotherapy-induced oral mucositis
Provisionally accepted
Peiyan Wang
Tianlu Wang
Hui ZhangPei Sun
Changqing YuanYiqing Guo
Zhaochen Liu
Mengyu JiaoJingwen Chi
Wang KexinJing Deng*Xiaofei Yu*- Department of Stomatology, Affiliated Hospital of Qingdao University, Qingdao, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Chemotherapy-induced oral mucositis is a common complication in cancer therapy. Multiple studies demonstrate that doxepin mouthwash is effective in controlling CIOM pain, while research on its ulcer healing effects and underlying mechanisms remains limited. Additionally, local adhesive formulations of doxepin for oral application are still lacking. In this study, we developed a bilayer oral patch using 3D-printing technology for the localized sustained release of doxepin hydrochloride. This patch demonstrated favorable characteristics, including thinness, flexibility, and excellent mucosal adhesion, while promoting ulcer healing in CIOM animal models. Further investigation revealed that the healing mechanism involves the alleviation of oxidative stress and attenuation of excessive inflammatory responses. The doxepin hydrochloride patch developed in this study provides a novel pharmaceutical option for clinical management of CIOM.
Keywords: Chemotherapy-induced oral mucositis, 3D printing, oral mucosal adhesive materials, Doxepin hydrochloride, Wound Healing
Received: 25 Jul 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Wang, Wang, Zhang, Sun, Yuan, Guo, Liu, Jiao, Chi, Kexin, Deng and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jing Deng, dengjing3333@126.com
Xiaofei Yu, yuxiaofei0532@qdu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.