REVIEW article
Front. Pharmacol.
Sec. Inflammation Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1678958
Epigenetic programming reshapes innate immune memory: decoding the molecular imprint of gouty inflammation
Provisionally accepted
- 1Department of Orthopedics, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China
- 2Graduate School of Hunan University of Chinese Medicine, Changsha, China
- 3Department of Orthopedics, the Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China
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Gout is an inflammatory joint disease caused by abnormal uric acid metabolism, characterized by the deposition of urate crystals in joints and surrounding tissues, leading to acute or chronic inflammatory responses. The etiology and pathogenesis of gout are complex, and there is currently a lack of ideal therapeutic drugs and treatment strategies. Epigenetic modifications influence and regulate gene function and characteristics through mechanisms such as DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA, thereby exerting significant effects on the physiological and pathological states of the body. Recently, epigenetic modifications and trained immunity in gout have garnered increasing research interest. Epigenetic modification-mediated trained immunity represents a frontier area in the study of gout pathogenesis. This review summarizes the latest findings on the role and regulatory mechanisms of epigenetic modifications in the development of gout, as well as the role of epigenetic remodeling-mediated trained immunity in gout and the potential applications of epigenetic intervention strategies in gout, providing new insights into the relationship between persistent inflammation, epigenetics, and innate immune memory in gout.
Keywords: Gout, epigenetic reprogramming, trained immunity, DNA Methylation, Histonemodification, Acetylation, non-coding RNA
Received: 03 Aug 2025; Accepted: 14 Oct 2025.
Copyright: © 2025 Su, Luo, Lu and Xiong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Xiong, 714123458@qq.com
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