MINI REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1681625
This article is part of the Research TopicReviews in Ethnopharmacology: 2025View all 39 articles
Protective effects of medicinal plant-derived metabolites in cardiovascular disease: from exosomal pathway
Provisionally accepted
- Shandong University of Traditional Chinese Medicine, Jinan, China
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Cardiovascular disease (CVD) is a highly prevalent and lethal disease worldwide, and existing conventional therapeutic drugs have limitations due to their side effects. Medicinal plant-derived metabolites have become a research hotspot due to their multi-target and multi-pathway cardioprotective potentials, while exosomal miRNAs, as core regulatory molecules of intercellular communication, play a key role in CVD such as atherosclerosis and myocardial infarction.This paper systematically reviews the mechanisms by which medicinal plant-derived metabolites regulate exosome miRNA or synergize with exosome therapy to protect CVD. For instance, Tanshinone IIA, Astragaloside IV, Paeonol, and Ginsenoside Rg1 can achieve effects such as promoting/inhibiting angiogenesis, anti-inflammation, and vascular remodeling by regulating exosomal miRNA expression. Finally, we look forward to the future direction of Medicinal plant-derived metabolites combined with exosomes in the protection of cardiovascular diseases, and provide a theoretical basis for the application of Medicinal plant-derived metabolites in CVD protection and the development of exosomal miRNA-targeted drugs.
Keywords: cardiovascular disease, Exosomes, miRNA, Medicinal plant-derived metabolites, Pharmacological effects
Received: 07 Aug 2025; Accepted: 13 Oct 2025.
Copyright: © 2025 Fu, Han, Lu, Song, Shen, Xiong, Liu and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanzhu Liu, yanzhuliu@sdutcm.edu.cn
Zu Gao, gaozu1203@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.