SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Different Traditional Chinese Medicine Injections Combined with Conventional Therapy for Sepsis-Induced Myocardial Dysfunction: A Systematic Review and Network Meta-analysis
Provisionally accepted
- 1Bejing University of Chinese Medicine, Beijing, China
- 2Beijing University of Chinese Medicine Dongfang Hospital, Beijing, China
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Objective: As the use of Traditional Chinese Medicine injections(TCMIs) for sepsis-induced myocardial dysfunction (SIMD) becomes increasingly diverse, this study aims to evaluate their efficacy, optimal combinations, and safety. Results: A total of 31 randomized controlled trials (RCTs) were included, comprising 2,166 participants (intervention group: n=1,099; control group: n=1,067). Nine TCMIs were investigated: Shenmai injection (SM), Danshen Chuanxiongqin injection (DSCXQ), Xuebijing injection (XBJ), Shenfu injection (SF), Shuxuening injection (SXN), Xinmailong injection (XML), Huangqi injection (HQ), Danhong injection (DH), and Shenqi fuzheng injection (SQFZ). Based on the surface under the cumulative ranking curve values, (1) In reducing 28-day mortality, Shuxuening Injection combined with conventional therapy ranked first based on the Surface Under the Cumulative Ranking Curve (SUCRA). (relative risk [RR], 3.67; 95% confidence interval [CI], 1.09 to 12.32). (2) For the improvement of cardiac troponin I (cTnI) levels, Danshen Chuanxiongqin Injection combined with conventional therapy ranked first based on SUCRA.(mean difference [MD], 0.87; 95% CI, 0.22 to 1.52). (3) In terms of left ventricular ejection fraction (LVEF) improvement,Shenqi Fuzheng injection combined with conventional therapy ranked first based on SUCRA. (MD, -8.79; 95% CI, -15.99 to -1.59). (4) For the reduction of B-type natriuretic peptide (BNP), Xinmailong injection combined with conventional therapy ranked first based on SUCRA.(MD, 353.37; 95% CI, 188.55 to 518.19). (5) Regarding the improvement of N-terminal pro-BNP (NT-proBNP), Danshen Chuanxiongqin injection combined with conventional therapy ranked first based on SUCRA.(MD, 557.45; 95% CI, 177.68 to 937.22). In addition, no significant adverse reactions were reported in the relevant studies on the Shenmai, Danshen Chuanxiongqin ,Shenfu, Shuxuening , Huangqi , Danhong and Shenqi fuzheng injections, whereas theXuebijing and Xinmailong injections demonstrated varying degrees of adverse reactions.
Keywords: Traditional Chinese medicine injections, Sepsis-induced myocardial dysfunction, Systematic review, Network meta-analysis, randomized controlled trial
Received: 18 Aug 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Deng, Huang and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Po Huang, huangpo1992@126.com
Xiaolei Fang, fxl586@vip.sina.cn
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