REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Preclinical Research of Dihydromyricetin for Fibrotic Diseases
Provisionally accepted
- 1Gansu Provincial Hospital, Lanzhou, China
- 2Southern Medical University, Guangzhou, China
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Fibrosis is a pathological condition characterized by excessive deposition of extracellular matrix (ECM) components, leading to tissue scarring and progressive organ dysfunction. The effective treatment of fibrotic diseases remains a pressing challenge in medical research. Dihydromyricetin (DHM), a principal bioactive flavonoid derived from Ampelopsis grossedentata, exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, and autophagy-modulating effects. This comprehensive review systematically analyzes current research to elucidate the molecular mechanisms underlying DHM's anti-fibrotic effects across various organ systems. Additionally, we assessed the compound's chemical properties and toxicological profile. This review aims to advance the understanding of DHM's therapeutic potential for fibrotic diseases, clarify associated molecular mechanisms, and highlight persistent challenges. We also propose new research directions to further decipher the mechanisms of action of this flavonoid, which may facilitate the development of novel therapeutic strategies for fibrotic diseases.
Keywords: Dihydromyricetin, Fibrosis, anti-inflammatory, antioxidant, Autophagy
Received: 26 Aug 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Wang, Mai, Yuan and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhi-Sheng Qiu
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.