ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1692910
Efficacy Analysis of Remifentanil Mild Sedation Anesthesia for Painless Gastroscopy
Provisionally accepted
- Yangquan Coal Industry Group Co., Ltd. General Hospital, Yangquan City, China
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Purpose: To investigate the clinical efficacy of remifentanil mild sedation versus propofol deep sedation for anesthesia during painless gastroscopy. Methods: A total of 980 patients undergoing painless gastroscopy at our hospital's endoscopy center from January to May 2025 were enrolled and randomly divided into a control group (490 cases, propofol-etomidate mixture intravenous injection) and an observation group (490 cases, remifentanil intravenous injection) using a computer-generated random sequence with sealed envelope allocation. Intraoperative vital sign changes, complication rates, time to ambulation, anesthetic dosage, and patient satisfaction were compared between the two groups. Results: The overall complication rate in the observation group was 0.6%, significantly lower than 64% in the control group (P<0.05). 76.3% of patients in the observation group experienced intraoperative blood pressure and heart rate fluctuations, compared to 78.6% in the control group, with no significant difference (P>0.05). The observation group demonstrated significantly shorter ambulation time (17±1.8 vs. 25±3.6 minutes, P<0.01) and higher satisfaction rates (patients: 92% vs. 94.4%; clinicians: 98% vs. 95%, P<0.05) than the control group. Multivariate logistic regression analysis showed that remifentanil use was an independent factor for reducing complications (OR=0.12, 95%CI:0.05-0.28, P<0.001). Conclusion: Remifentanil intravenous injection combined with lidocaine gel for mild sedation anesthesia effectively alleviates discomfort during gastroscopy. Compared with propofol-based deep sedation, it demonstrates a lower complication rate and higher safety.
Keywords: remifentanil, sedation, Painless gastroscopy, Propofol, complications, Anesthesia recovery
Received: 26 Aug 2025; Accepted: 22 Oct 2025.
Copyright: © 2025 Xi, Zhang, Gu, Wang, Qu, Mao, Mi and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dongfeng Xi, xidongfeng78@163.com
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